MESP1 and breast cancer: To determine whether rat cells were capable of heat generation in the interspecies BC method using the Mesp1/2-DKO mouse model, we injected rat ESCs (green fluorescent protein (GFP)+) into the blastocysts obtained by interbreeding the Mesp1/2-DHet males and females (donor: rat ESCs; host: Mesp1/2-DKO or non-Mesp1/2-DKO embryos) (Figure 6A) (Table 4).