For example, PAX6 was differentially enriched in CF PDEs on day 2 and higher in CF PDEs relative to WT PDEs at all time points (Figures 4B, 4C and Tables S5A–S5D), suggestive of endocrine differentiation71 and/or a phenotype similar to early duct/endocrine progenitors.72 Here, PAX6 is linked to cystic fibrosis.