Additionally, NR5A2 (Log2FC = 3.9, p = 3.2E−08), a trunk-specific transcription factor known for its role in maintaining the progenitor population55 and generation of acinar cells during development,56 and PROM1 (Log2FC = 2.94, p = 0.00474), a duct epithelial progenitor marker,57 were both differentially open in CF PDE (Table S3A). This evidence concerns the gene NR5A2 and cystic fibrosis.