Like CF centroacinar progenitors, DEGs in CF centroacinar cells included upregulation of endocrine lineage genes ID2 and ID3 (Table S6E and S6F), but also enhanced expression of WNT mediator CTNNB1102 (Table S6F) and PI3K signaling subunit PIK3R1, and downregulation of ductal genes like MUC1 and KRT8 (Tables S6E and S6F and Figure 5E). Here, PIK3R1 is linked to cystic fibrosis.