Genomic loci of endocrine progenitor transcription factors PDX1 (Log2FC = 4.3, p = 2.94E−27) and PAX6 (Log2FC = 2.25, p = 1.9E−05) among others were significantly more open in CF as compared to WT PDE cultures (Figure 3B and Table S3A), consistent with enhanced PDX1 expression in CF PDE cultures (Figure 1J and Table S1A). Here, ALDH7A1 is linked to cystic fibrosis.