BCL2 and Familial prostate cancer: In the prostate cancer cell lines LNCaP and PC3, the depletion of METTL3 results in increased expression levels of the pro-apoptotic proteins Bak and Bax, alongside heightened activity of caspase3 and caspase7, while simultaneously decreasing the expression levels of the anti-apoptotic proteins Bcl-2 and Bcl-xl (Cai et al., 2019).