In lipopolysaccharide (LPS)-induced endotoxemia, METTL3 controls neutrophil release from the bone marrow into the circulation in a TLR4-signaling-dependent mechanism involving surface expression of CXC chemokine receptor 2 (CXCR2) (Luo et al., 2023). Here, TLR4 is linked to serum lipopolysaccharide activity.