GSEA confirmed marked activation of immune-associated signaling pathways in the ICD-high subtype, including the T-cell receptor signaling pathway, phagocytosis mediated by FcγR, etc. Of the DEGs, 17 were ICD-associated genes, including CXCR3, CD8A, IFNG, IL1B, IL10, NT5E, CD8B, IL6, TNF, PRF1, FOXP3, CD4, NLRP3, TLR4, LY96, CASP1, and P2RX7, all of which were up-regulated in ICD-high subtype. Here, CASP1 is linked to impulse control disorder.