SPON2 and Bloom syndrome: To further, we explored the expression levels of differential genes by GO analysis between BLM and Normal, and the results showed that, except for the abnormal expression of genes related to cell migration and invasion (Wnt5a, Postn, and Spon2), and apoptosis (Ripk2, Casp3, and Atf2), the expression level related to immune response in BLM group was significantly higher than that in Normal group (Figure 2E).