qPCR analysis demonstrated that, compared with that in BLM‐SSc WT mice, the expression of fibrosis‐related genes (α‐SMA, Postn, Col1A1, Col1A3, Fn1, Timp1, Vimentin, and connective tissue growth factor, Ctgf) were downregulated in BLM‐SSc KO mice. Here, CCN2 is linked to Bloom syndrome.