Additionally, stimulation of SSc DFs with rChi3L1 led to the increased secretion of interleukin‐11 (IL‐11), a classic pro‐fibrotic molecule autocrinely secreted by fibroblasts in SSc (Figure 3I).[29, 30, 31] All these data validated the ability of Chi3L1 to effectively boost SSc DF activation. This evidence concerns the gene CHI3L1 and systemic sclerosis.