The corresponding proteins related to these pathways, including IL‐17RA, were also upregulated in patients with SSc, consistent with previous studies (Figure S9C, D, Supporting Information).[44] The above evidence suggests that NF‐kB and P38/ERK MAPK pathway activation may be the major pathway involved in Chi3L1‐mediated fibrosis in SSc. This evidence concerns the gene IL17RA and systemic sclerosis.