ZEB1 and hepatocellular carcinoma: On one hand, it was reported that PA impaired HCC development by modulating membrane fluidity and glucose metabolism;[18] On the other hand, PA promoted HCC cell migration by inducing IRE1–XBP1–ZEB signaling.[19] Another report showed that PA rewired lipid metabolism, regulating HCC progression in a PHF2/SREBP1c axis‐dependent manner.[20] Despite multiple mechanisms underlying these conflicting results, there is currently no convincing and accepted explanation for the differential roles of PA in cancer progression.