KIBRA has been recently gained great attention as it mediates a novel molecular mechanism underlying the upstream regulation of Hippo pathway, i.e., KIBRA forms biomolecular condensates to activate Hippo signaling.[90, 91] Accumulating evidence suggests KIBRA functions as a tumor suppressor in the progression of various cancers,[92, 93, 94] however, it remains poorly understood how KIBRA is regulated during cancer development. The gene discussed is WWC1; the disease is cancer.