By performing brightfield lung imaging (Figure S11G, Supporting Information), H&E and IHC staining (Figure S11H,I, Supporting Information), determining body weight (Figure S11J, Supporting Information), counting the number of lung metastatic lesions (Figure S11K, Supporting Information), and calculating the survival rate (Figure S11L, Supporting Information), we showed that compared to ZDHHC15 WT, the DHHS mutant lost its ability to promote cancer metastasis. Here, ZDHHC15 is linked to cancer.