We found that PA treatment enhances KIBRA palmitoylation and degradation in a ZDHHC15‐dependent manner, consistent with previous studies showing that PA promotes protein palmitoylation.[64, 65] Moreover, decreased KIBRA expression and concomitantly increased expression of YAP target genes were observed in tumor samples from mice supplemented with a Palm‐diet. Here, ZDHHC15 is linked to neoplasm.