On one hand, it was reported that PA impaired HCC development by modulating membrane fluidity and glucose metabolism;[18] On the other hand, PA promoted HCC cell migration by inducing IRE1–XBP1–ZEB signaling.[19] Another report showed that PA rewired lipid metabolism, regulating HCC progression in a PHF2/SREBP1c axis‐dependent manner.[20] Despite multiple mechanisms underlying these conflicting results, there is currently no convincing and accepted explanation for the differential roles of PA in cancer progression. Here, ERN1 is linked to hepatocellular carcinoma.