PA‐induced YAP target gene expression and cancer cell invasion were severely blunted in ZDHHC15‐depleted HCC1954 and TOV‐112D cells compared to their matched control cells (Figure 5B; Figure S14B, Supporting Information), and these effects upon ZDHHC15 depletion could be rescued by ZDHHC15‐WT but not the ZDHHC15‐DHHS mutant (Figure S14B, Supporting Information), indicating that ZDHHC15 abundance and its palmitoyltransferase activity are essential for PA‐mediated regulation of YAP activity in vitro. This evidence concerns the gene ZDHHC15 and cancer.