In the gain‐of‐function screen, we overexpressed each of the 23 Flag‐tagged or V5‐tagged human ZDHHC palmitoyltransferases together with the TEAD‐luciferase constructs in HCC1954 and T47D breast cancer and PEO‐4 and TOV‐112D ovarian cancer cell lines and found that ZDHHC15 but not the other ZDHHCs, significantly enhanced TEAD transcriptional activity in the tested 4 cell lines (Figure 2B; Figures S6D and S7A, Supporting Information). Here, ZDHHC15 is linked to ovarian carcinoma.