These findings were consistent with literature hypothesis that tumor‐reactive CD8+ T cell responses were present in TLS.[32] Clinically effective HAIC therapy facilitated the infiltration of Granzyme‐K+PD‐1+CD8+ T cells with functionally antitumor phenotypes, which was another synergetic mechanism with PD‐1 blockade. The gene discussed is CD8A; the disease is neoplasm.