Increasing evidence suggests that cancer therapies, such as chemotherapy, radiotherapy, and immunotherapy, exert a profound effect on the formation and maturation of TLSs.[25] Given the enhanced interactions and spatial co‐localization between CD4+ T, cDCs, and CD20+ B cells following HAIC therapy, we next sought to address whether HAIC could induce the formation of TLSs. The gene discussed is CD4; the disease is cancer.