Even though fibroblasts were reported to adopt CXCL12‐CXCR4 axis to restrain T cell response in pancreatic cancer,[49] it has also been shown that CXCL12‐producing fibroblast mediate lymphocyte migration.[50, 51] Recently, the co‐occurrence of expression of fibroblast signatures and CXCL12 was detected by spatial transcriptomics and multiplex IHC in renal cell cancer,[52] highlighting the roles of CXCL12‐producing fibroblasts for migration and dissemination of plasma cells from TLSs deeper into the tumor cores. This evidence concerns the gene CXCR4 and renal cell adenocarcinoma.