Among them, C05_Fb_DCN expressed highest levels of CXCL12, DCN, and IGFBP3 (Figure 6D), which was consistent with Qin et al.’s remodeled CAF subtypes and was strongly associated with chemotherapy response.[34] The remodeled CAF subtypes were reported to regulate the TME through spatial recruitment and crosstalk to activate immunity, and suppress tumor progression through multiple cytokines, including CXCL12, and DCN. Here, IGFBP3 is linked to neoplasm.