Following persistent exposure to tumor‐associated antigen, tumor‐specific CD8+ T cells displayed an exhausted state, which was characterized by up‐regulation of co‐inhibitory molecules and the progressive loss of proliferative capacity.[28, 29] According to previous studies, tumor‐specific CD8+ T cells were largely composed by progenitor‐exhausted and terminal‐exhausted T cells.[30, 31] Our analysis revealed similar results. Here, CD8A is linked to neoplasm.