These spatial findings indicated that intermediate‐exhausted CD8+ T cells might accumulate at TLSs, which was consistent with the literature hypothesis that tumor‐reactive CD8+ T cell responses are present in TLSs.[32] Additionally, PD‐1+CD8+ Tex‐int cells in cluster C03_CD8T_DTHD1 are suggested to highly express Granzyme‐K but moderately express PD‐1. Here, PDCD1 is linked to neoplasm.