To investigate the clinical relevance of intermediate‐exhausted CD8+ T cells, survival analysis of TCGA‐LIHC and Fudan‐HCC databases revealed that C03_CD8T_DTHD1 signature was associated with a better prognostic outcome in HCC patients (Figure 5C; Figure S6C, Supporting Information). This evidence concerns the gene CD8A and hepatocellular carcinoma.