These results were supported by recent studies on HCC: PD‐1hiCD8+ T cells in Magen et al.’s study[14] and CD8_C4_LAYN cluster in Tan et al.’s study[46] were specifically enriched in tumor microenvironment and validated as tumor‐reactive CD8+ T cells by scTCR‐seq. This evidence concerns the gene CD8A and neoplasm.