It also promotes type I interferons (IFN-Is) responses and increases serum IFN-γ levels, thereby accelerating the onset and progression of SLE.[51] Galectin-3 binds to CD98, a type II transmembrane heterodimer, and enhances IL-4-mediated macrophage activation through the PI3K pathway. The gene discussed is LGALS3; the disease is systemic lupus erythematosus.