NFKB1 and atherosclerosis: Activated NLRP3 inflammasomes drive atherogenesis and progression of atherosclerosis through the NF-κB signaling pathway, producing Caspase-1, IL-1β, and IL-18.[55] Activation of NLRP3 inflammatory corpuscles also leads to a systemic inflammatory response, indirectly stimulating neutrophil activation.