The second most prevalent gene in familial DCM is LMNA (which encodes LAMIN A/C), be responsible for nearly 5% to 10% of all familial DCM cases.[4] We have previously identified a novel insertion mutation (nucleotide 1526insA, amino acid T510Y) in LMNA carried by a young female in a family with dilated cardiomyopathy, conduction system disease and sudden cardiac death.[5] However, genetic basis of most DCM patients keeps unknown and require further study. The gene discussed is LMNA; the disease is dilated cardiomyopathy.