LAMA4 and familial dilated cardiomyopathy: In hundreds of Caucasian patients with severe DCM, Knoll et al found 1 individual carrying a LAMA4 c.3217C > T (p.R1073X) mutation and 2 individuals carrying a LAMA4 c.2828C > T (p.P943L) mutation.[15] The 2 DCM patients with the c.2828C > T mutation were sporadic and without a genetic relationship.