The recurrence rate of liver cancer is particularly high, especially in advanced cases.[32,33] It is widely acknowledged that factors such as tumor differentiation, tumor size, lymph node metastasis, and pathological stage are associated with the recurrence of liver cancer.[34,35] Our study showed that serum PTX3 levels were significantly correlated with TNM stage, tumor size, and lymph node metastasis in liver cancer (Table 2). Here, PTX3 is linked to neoplasm.