Pentraxin-3 (PTX3), a glycoprotein secreted by immune cells, plays an important role in inflammation, immune responses, apoptosis, and vascular remodeling.[11,12] PTX3 promotes cellular proliferation, angiogenesis, and resistance to apoptosis, facilitating cancer cell invasion and growth via the AKT and NF-κB signaling pathways.[11] It also helps cancer cells evade immunosurveillance. This evidence concerns the gene NFKB1 and cancer.