Additionally, TREM-2 forms a receptor signaling complex with transmembrane immune signaling adaptor (TYROBP) to activate the immune response of macrophages and dendritic cells.[40] It activates dendritic cells derived from monocytes and serves as a phagocytic receptor to recognize and bind to certain bacteria and fungi, enhancing microbial clearance to strengthen the host’s immune response.[41] This contrasts with the mechanism of our inflammatory response, suggesting that the causal relationship between TREM-2 and periodontitis warrants further investigation. Here, TREM2 is linked to periodontitis.