Currently, a number of scholars agree that the reason of osteolysis caused by GCT is that osteoblast-like mononucleostromal cells overexpress RANKL or TNF-related activated inducer cytokines, stimulate the recruitment of osteoclasts into osteoclast-like giant cells, and actively enable host bone absorption.[2–4] Because bone destruction can lead to bone defects and pathological fractures, surgical treatment is often required, and there is no consensus on the ideal treatment. Here, TNFSF11 is linked to granular cell tumor.