According to the IVW results, there was no significant causal relationship between RANK (OR = 0.973, 95% CI = 0.871–1.087, P = .626) and RANKL (OR = 1.048, 95% CI = 0.938–1.171, P = .411) and scoliosis. The gene discussed is TNFSF11; the disease is scoliosis.