Statistical differences were observed between the 2 groups regarding the covariates of gender, age, education level, marital status, race, PIR, smoking status, alcohol consumption, BMI, Hemoglobin (HG), ALT, AST, LDH, potassium, uric acid, albumin, serum iron, calcium, creatinine, HDL-C, TC, diabetes, and hypertension (all P < .05) (Table 1). This evidence concerns the gene GDF15 and hypertensive disorder.