In the group with severe respiratory failure, the factors of age, Charlson comorbidity index, serum CRP, ferritin and procalcitonin levels, neutrophil count, upper and middle zone CT scores in both lungs, remdesivir usage, and diabetes with end-organ damage rate were higher; lymphocyte counts and the decrease in CRP on the third day were lower than in the group without severe respiratory failure. The gene discussed is CRP; the disease is diabetes mellitus.