However, plasma adipsin concentration (Figure 1a), fasting serum C-peptide concentration (Figure 1b), 2-h C-peptide concentration (Figure 1c), and 2-h C-peptidogenic index (Figure 1d) in the T2D-with-insulin group were significantly decreased compared with the T2D-w/o-insulin group. Here, CFD is linked to type 2 diabetes mellitus.