CYP27B1 and Cowden disease: Regarding CYP27B1 −1260 GT, heterozygous individuals with this mutation exhibit a 3.1-fold increased likelihood of having non-ileal CD (non L1-CD), though the p-value approached the threshold for significance (OR = 3.13, 95% CI: 0.98–10.01, p = 0.054).