In a prospective cohort of 300 asthmatic children ages 4–12 followed for 1 year, sensitization of Der p 1 house dust mite allergen and pet allergens were associated with asthma severity, but Der p 1 remained an independent risk factor after accounting for pet allergens and regardless of Der p 1 specific IgE status [38]. The gene discussed is IGHE; the disease is asthma.