The distribution of clinical variables, allergic sensitization, sputum and peripheral blood eosinophils, sputum cellularity profiles, total IgE, FeNO, and serum periostin levels were similar in the groups of children with never controlled asthma and sometimes/always controlled asthma, except for a significantly higher duration of asthma and symptomatic patients (ACT score < 20) in the group of uncontrolled asthma, with exacerbations in the previous year and use of systemic corticosteroids also being more frequent and marginally statistically significant. This evidence concerns the gene POSTN and asthma.