LUM+ tumor cells were mainly enriched in proteoglycans in cancer and extracellular matrix organization and demonstrated expression of the MMP2, MMP14, COL1A1, COL6A2, and COL1A2 genes, associated with extracellular matrix remodeling (Figure 3C and Figure 4A, Supplementary Table S1). This evidence concerns the gene COL1A1 and neoplasm.