Methods: For a better understanding of both conditions, our research was conducted in two directions: one reviewing the literature on patients with Coxiella burnetii BCNIE and the other focusing on patients who had a familial thoracic aortic aneurysm (FTAA) due to the ACTA2 variant. Here, ACTA2 is linked to marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections.