In addition to cardiovascular disorders, pathogenic variants of the ACTA-2 gene predispose patients to other forms of vascular pathologies, including Moyamoya-like occlusions that can lead to early onset of cerebrovascular events or occlusions of internal carotid arteries or intracranial aneurysms [8,9,10]. The gene discussed is ACTA2; the disease is Dilatation of the cerebral artery.