Arteries from patients with CKD show a dysregulation of inflammation linked to the prostaglandin pathway, manifested by an enhanced expression of COX-2/cPLA-2 [20], and a significant decrease in the expression of prostacyclin synthase (PTGIS) [19], the membrane enzyme producing the anti-inflammatory prostaglandin, prostacyclin (PGI2). The gene discussed is PTGIS; the disease is chronic kidney disease.