TNNI3 and obesity due to melanocortin 4 receptor deficiency: On the other hand, the differences observed in hs-cTnI and hs-cTnT assays appear promising and highlight the need to adjust thresholds for hs-cTn in population screening, not only based on sex but also considering the presence of other cardiometabolic risk factors such as obesity, diabetes and decreased renal function.