On the other hand, the differences observed in hs-cTnI and hs-cTnT assays appear promising and highlight the need to adjust thresholds for hs-cTn in population screening, not only based on sex but also considering the presence of other cardiometabolic risk factors such as obesity, diabetes and decreased renal function. The gene discussed is TNNT2; the disease is obesity due to melanocortin 4 receptor deficiency.