Patients with obesity presented with albuminuria, lower serum adiponectin (p  =  0.005), and higher urine Gal-3 concentrations (p  =  0.004).Compared to controls, the “Decreased GFR” group showed higher serum uric acid (p  =  0.004), triglycerides (p  =  0.037), and cholesterol (p  =  0.043) levels as well as significantly higher NGAL urine concentration and daily urine megalin excretion (p  =  0.005).“Normal GFR” obese patients presented a strong correlation between urine Gal-3 concentration and urine NGAL concentration (p = 0.001, r = 0.706). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.