In the context of obesity, dyslipidemia has been demonstrated to increase leptin and reduce adiponectin levels, triggering a pro-inflammatory immune response (IFN+/IL17+CD4+ T cells) while reducing levels of cells modulating the inflammatory response (Foxp3+CD4+ T cells) [23,42]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.