117 children with CKD classified according to disease severity as stage I–II (eGFR > 60 mL/min/1.73 m2) or stage III–V (eGFR < 60 mL/min/1.73 m2). Overweight was defined as a BMI of >85th percentile for age and sex, and obesity was defined as a BMI of >95th percentile.Hypertension was defined as SBP of >95th percentile for age, sex, and height or receipt of one or more antihypertensive agents (excluding the use of angiotensin-converting enzyme inhibitors for proteinuria).eGFR was calculated using a modified Schwartz formula. Here, ACE is linked to obesity due to melanocortin 4 receptor deficiency.