Those results, where blood pressure reduction and improvements in HF symptoms represent the main purpose in this section, can be completed with detailed discussions of renal mechanisms, such as the interaction between the Na+/H+ exchanger isoform 3 (NHE3) and SGLT2 inhibitors, macula densa signalling, and adenosine receptor-mediated effects. Here, SLC5A2 is linked to hydrops fetalis.