According to WHO-HAEM5, cases carrying either an isolated MYC rearrangement or MYC and BCL2 abnormalities other than typical translocations or dual MYC and BCL6 rearrangements should be placed in the category either of DLBCL, NOS or HGBCL depending on their morphology. The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.