HGBCL-DH-BCL6 carry less frequently mutations recurrent in HGBCL-DH-BCL2 such as CREBBP, KMT2D, EZH2, CCND3 and ID3, whereas they show mutations in genes such as CD79B and PIM1, which are associated with non-GCB DLBCL [1,37,45]. The gene discussed is CCND3; the disease is diffuse large B-cell lymphoma.