In the previous 2017 WHO classification (WHO-HAEM4), these lymphomas, known as DH or triple-hit (TH) lymphomas, were placed in a provisional category of high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements (HGBCL-DH/TH) [3]. The gene discussed is MYC; the disease is lymphoma.