In instances of high fat diet-induced diabetes accompanied by obesity, a distinct pattern emerges wherein adipose tissues experience an accumulation of p21Cip1-highly expressing p21high cells during the early stage, followed by an increase in both p21high and p16 Ink4a-highly expressing (p16high) cells in the later stage. The gene discussed is CDKN1A; the disease is obesity due to melanocortin 4 receptor deficiency.