CFL1 and cancer: Among genes in the category “proteoglycans in cancer” were Col1a2, collagen type III alpha 1 chain (Col3a1), matrix metalloproteinase-2 (Mmp2) and Fn1, recapitulated in the chemoresistant ECM in PDAC, while the categories “pathways in cancer” included the genes Fgfr1, Bax, Cfl1, Calm1 and Cdk2, which are involved in cell survival, migration and proliferation (Figure S5).