TYR and melanoma: Along with the results observed in B16 mouse melanoma cells, the relative gene expression levels of MITF, TYR, TRP-1, and DCT, after exposure to IBMX treatment, were significantly upregulated to 1.65 ± 0.12, 1.73 ± 0.15, 1.53 ± 0.12, and 1.67 ± 0.13, respectively, compared to the control group.