In the case of the peel extract from M. sapientum AA group ‘Leb Mu Nang’, the finding suggested that this extract could inhibit melanin content in B16 melanoma cells by downregulating the protein expression of MITF, TYR, and melanosome transfer markers, including Ras-related protein (Rab) 27a and premelanosome protein 17 (Pmel17) [22]. The gene discussed is MITF; the disease is melanoma.