AKT1 and Alzheimer disease: The study also found that the interactions between AD-related proteins AKT1, GSK3B, NFκB1, BACE1, and potential compounds from MS, such as acetylursolic acid, beta-sitosterol, isomitraphylline, and speciophylline, showed significant binding affinities and hydrogen bonding, as shown in Table 3, suggesting their potential as therapeutic targets.