This receptor has been associated with anti-fibrotic and anti-inflammatory effects in the heart, as well as anti-proliferative and anti-angiogenic effects in cancer due to a local decrease in angiotensin II levels or AT1R blockade, which results from high concentrations of angiotensin 1-7 at the tumor site [4,101] (Figure 1). The gene discussed is AGTR1; the disease is neoplasm.