GPBP1 and Autoimmunity: To achieve this overarching goal, we have outlined specific secondary objectives, which include describing the molecular and biochemical characterization of GPBP/CERT, providing a bibliometric analysis of the existing literature on GPBP/CERT in the context of autoimmunity, cancer, and neurodegenerative diseases, and assessing the current status of the two proposed hypotheses regarding the functions of GPBP/CERT.