This study noted that, along with the metabolic switch to glycolysis, tumour-derived hyaluronan also induced increased expressions of PD-L1 on the tumour-infiltrating monocytes/macrophages in HCC tumours and peritumoural infiltration with PFKFB3+CD68+ cells correlated with poorer survival in HCC patients [122]. This evidence concerns the gene PFKFB3 and hepatocellular carcinoma.