Furthermore, HCC TAMs can directly regulate the tumouricidal activity of CD8+ T cells by their expression of PD-L1 [165]; indeed, TAMs are the major expressor of PD-L1 within the HCC TME [122,167,168] and are spatially located in close proximity to infiltrating PD-1highTIM3+ CD8+ T cells [169]. The gene discussed is CD274; the disease is hepatocellular carcinoma.