CCR2 is the cognate receptor to the CC-chemokine, monocyte chemotactic protein 1 (MCP-1), also known as CCL2, which is widely secreted by hepatocytes, Kupffer cells, hepatic stellate cells, liver sinusoidal endothelial cells and HCC tumour cells [59,60,61,62,63]. Here, CCL2 is linked to hepatocellular carcinoma.