Regarding genes that are downregulated in IPMN-derived PDACs, decreased ALPP may be linked to others’ research indicating that the alkaline phosphatase to albumin ratio is a prognostic indicator for PDAC after curative resection [61], but not much has been published about C6orf15 except that it appears on a gene fingerprint predictive of poor survival in PDACs [62]. Here, ALPP is linked to pancreatic intraductal papillary-mucinous neoplasm.