Genes regulating transcription play an important role in the DCM, with rare mutations reported in T-box transcription factor 20 (TBX20), NK2 homeobox 5 (NKX2-5), GATA Binding Protein 4 (GATA4), GATA6, Forkhead Box D4 (FOXD4), PR domain containing 16 (PRDM16), EYA transcriptional coactivator and phosphatase 4 (EYA4), GATA Zinc Finger Domain Containing 1 (GATAD1), and RNA binding motif protein 20 (RBM20) [64,65]. Here, GATA4 is linked to familial dilated cardiomyopathy.