SNRPD2 and cancer: Interestingly, recent investigations revealed that Sm genes are overexpressed in a multitude of cancers [23,24,25,26,27] and that the depletion of SmD2, one of the spliceosome core components that we prioritized for targeted treatment development, inhibited the proliferation of hepatocellular carcinoma cells [24] and triple-negative breast cancer cells [28].