TNFRSF1A and coronary artery disorder: It is worth mentioning that studies conducted by Rossi et al. on gastric carcinogenesis, which has a similar basis to CAD inflammation, showed that the up-regulation of cell survival genes, e.g., TNFR2 of this signaling pathway in gastric carcinoma, stimulates cell growth, possibly by TNFR2, and negatively controls TNFR1-mediated apoptosis by the down-regulation of pro-apoptotic mediators [18].