HCRT and early-onset autosomal dominant Alzheimer disease: Moreover, the dysfunction of the orexin system was demonstrated not only in Alzheimer’s disease but also in chronic neuropsychiatric conditions such as schizophrenia, bipolar disease, epilepsy, and drug addiction; in neuroinflammatory diseases such as MS, neuromyelitis optica, and autoimmune narcolepsy; and in numerous neurodegenerative disorders in addition to Alzheimer’s disease, such as dementia with Lewy bodies, Parkinson’s disease, FTD-ALS spectrum, and Huntington’s disease [375,387,388,389,390,391,392,393].