Since sleep disorders, obesity, type II DM, permanent anxiety, chronic stress, and PTSD are all implicated in the pathogenesis of Alzheimer’s disease [73,74,75,76,373,374], it is not surprising that numerous experiments have been conducted to clarify the putative role of orexins in the development of Alzheimer’s disease [375,376]. Here, HCRT is linked to early-onset autosomal dominant Alzheimer disease.