VEGFA and proliferative diabetic retinopathy: Furthermore, there is cross-talk involved in mitochondria-induced angiogenesis, focusing on Vascular Endothelial Growth Factor (VEGF) signaling where the oxidative state produced by a dysfunctional mitochondria amplifies excess ROS, impairing the homeostatic maintenance of the vasculature and inducing angiogenesis, characteristic of Proliferative Diabetic Retinopathy (PDR) [5,23,26,27,28,29].