ACHE and early-onset autosomal dominant Alzheimer disease: The impact on enzyme activity was examined for enzymes involved in Alzheimer’s disease pathology, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as for the sodium pump, Na+, K+-ATPase, which is overexpressed in certain tumours and considered a potential target in antitumour drug development.