Although the cells in MDABM exhibit reduced drug resistance, the production of osteocalcin and other biochemical factors (e.g., Ca2+, MMPs, miRNAs) could stimulate un-trans-differentiated cancer cells to increase their proliferation and the production of MMPs, with a reduction in matrix stiffness and, consequently, an increase in cell migration and metastasis. The gene discussed is BGLAP; the disease is cancer.