AKT1 and colorectal carcinoma: Furthermore, AIM2 limited the proliferation of CRC cells, inhibiting cell viability, acting on the cell cycle by blocking cells at the G1/S transition level and promoting apoptosis via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/P38 mitogen-activated protein kinase (MAPK) signaling pathways [41,56,57].