Similarly, A438079, a selective and competitive P2X7 receptor antagonist, affected CRC cell line proliferation, invasion, and migration, in addition to inducing apoptosis via the Bcl-2/caspase-9/caspase-3 pathway and pyroptosis through the NLRP3/caspase-1 pathway [132]. This evidence concerns the gene NLRP3 and colorectal carcinoma.