One-carbon metabolism deregulation in hepatoblastoma tumors implicated 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), aldehyde dehydrogenase 1 family member L2 (ALDH1L2), and methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1-like (MTHFD1L). This evidence concerns the gene MTHFD1L and hepatoblastoma.