In 2020, Amy S. Paller et al. demonstrated a remarkable 75% reduction in IL17RA protein expression, along with a substantial decrease in the mRNA levels of psoriasis markers such as Defb4, IL17C, S100A7, PI3, KRT16, and TNFα compared to a control using scrambled spherical nucleic acid (Scr SNA) [120]. The gene discussed is TNF; the disease is psoriasis.