Three LGG patients were IDH—wildtype; one patient carried TRIM33–NTRK2 fusion; two other patients had genotypes more specific for HGG tumor types (CDKN2A deletion, PTEN mutation, and PTEN deletion in one case and TERTp mutation, PTEN mutation, and NF1 mutation in another). The gene discussed is IDH2; the disease is neoplasm.