Mutational profiling of glioblastoma samples from our patients included recurrent mutations TERTp (71.8%), PTEN (37.3%), TP53 (27.3%), EGFR (13.6%), NF1 (11.8%), RB1 (11.8%), PIK3CA (4.5%), PIK3R1 (4.5%), PTPN11 (4.5%), SPTA1 (3.6%), PIK3CB (1.8%), and MTOR (1.8%). This evidence concerns the gene PIK3R1 and glioblastoma.