RB1 and neoplasm: As stated above, the inactivation of RB by E7 releases E2F transcription factors that would activate promoters with E2F binding sites, including miRNA promoters of miR-449 and the miR-17~92 cluster (miR-17, miR-18a, miR-19a/b, miR-20a, and miR-92a-1) [235] and its paralog clusters miR-106a~363 (miR-18b, miR-19b-2, miR-20b, miR-92a-2, miR-106a, and miR-363) and miR-106b~25 (miR-25, miR-93 and miR-106b) [236], which are referred to as pro-tumor miRNAs or oncomiRs [237].