The TCGA project has identified recurrent mutations that ostensibly lead to invasive CC in PIK3CA, FBXW7, MAPK1, PTEN, EP300, NFE2L2, CASP8, TK11, HLA-A, and HLA-B genes, which are frequent in squamous CC, while ELF3, CBFB, KRAS, and ARID1A are enriched in cervical adenocarcinoma [267]. This evidence concerns the gene CASP8 and cervical adenocarcinoma.