Still, by combining histopathological and MRI analyses, Giannini et al. [54] recently focused on genetically defined FTD cases, considering both FTD-tau cases due to MAPT/TAU mutations and FTD-TDP cases linked to the hexanucleotide large expansion mutation in the C9orf72 gene. This evidence concerns the gene C9orf72 and frontotemporal dementia.