RNA editing modifications were analyzed using a panel of eight genes (CAMK1D, GAB2, IFNAR1, KCNJ15, LYN, MDM2, PDE8A, PRKCB; see details in Supplementary Material) that we previously identified and whose editing combinations were suggested as biomarkers to distinguish BD from unipolar depression [38] and subcategories of BD patients [39]. Here, PRKCB is linked to major depressive disorder.