VEGFA and cardiac hypertrophy: In particular, the expression of miR-34a increases in the heart during myocardial hypertrophy caused by stretching, adrenergic stimulation and hypoxia, which has been shown to contribute to the disruption of angiogenesis by uncoupling hypoxia-inducible factor 1-α–VEGF (HIF-1α-VEGF) signaling [19].