BAG3 and cardiomyopathy: A previous study found that reduced left ventricular ejection fraction and increased left ventricular end-diastolic diameter were associated with BAG3 mutation-related cardiomyopathy, and, in a histologic analysis, myocardial tissue from patients with a BAG3 mutation exhibited myofibril disarray and relocation of the BAG3 protein in the sarcomeric Z-disc [37].